The Tribe (8-11, 2-6 Colonial Athletic Association) scored 11 straight points after falling behind 54-52 on Marcus Damas' layup with 3:42 remaining.
W&M got 16 points from Marcus Thornton, 14 apiece from Tim Rusthoven and Kyle Gaillard and 12 from Brandon Britt.
Rusthoven grabbed 10 rebounds for W&M, which held Tigers double-double machine Jerrelle Benimon to 12 points and six rebounds. W&M committed just eight turnovers.
CNU 78, Methodist 57
Tra Benefield had 25 points and a career-high 15 rebounds as Christopher Newport registered a win over Methodist at Freeman Center.
The Captains (15-2, 8-1), who lead the USA South and are ranked 15th nationally by d3hoops.com, led just 45-43 at the 12-minute mark. But Connor Laframboise's layup with 11:53 left ignited a 13-2 run that put CNU in control.
Mike Cherry added 14 points for the Captains, and freshman Evan Thorpe had 13 points and seven rebounds.
For Methodist, Bryan Hockaday had 11 points and six rebounds.
After winning 13 consecutive games, the Rams dropped their second in a row, putting their top-25 ranking in major jeopardy.
Ramon Galloway scored a career-high 31 points at Siegel Center, and La Salle accomplished a feat it hadn't achieved in 61 years.
Fresh off a dramatic 54-53 last-second win over No. 9 Butler on Wednesday, the Explorers knocked off a ranked foe in back-to-back games for the first time since the 1952 National Invitation Tournament, overcoming an eight-point deficit with less than 15 minutes left behind Galloway's big performance and a strong defensive effort.
La Salle (14-5, 4-2 Atlantic 10) held the Rams (16-5, 4-2) to just 38.3 percent shooting for the game and a 4-of-16 success rate from 3-point range.
Galloway netted 20 of his points after halftime to lead the comeback, with Tyreek Duren contributing 16 points and Steve Zack pulling down 11 rebounds to help the Explorers prevail.
Juvonte Reddic had 22 points on 9-of-13 shooting and grabbed 10 rebounds for the Rams, who fell in overtime at rival Richmond on Thursday. Treveon Graham finished with 13 points and 12 rebounds.
JMU 56, ODU 46
Andre Nation had 14 points and eight rebounds as James Madison defeated last-place Old Dominion to complete a two-game sweep of the Monarchs for the first time in 13 years.
Fellow freshman Ron Curry added 12 points for JMU (11-10, 5-3 CAA)as it picked up its second consecutive decision. Devon Moore chipped in 10 points for the Dukes.
Keenan Palmore provided a spark off the bench with 13 points, but the Monarchs (2-17, 0-7) lost for the seventh time in a row. Freshman Aaron Bacote from Bethel High contributed 10 points, while DeShawn Painter had nine points and nine rebounds.
Southern Va. 96, Apprentice 87, OT
Southern Virginia (11-3) controlled overtime against U.S. Collegiate Athletic Association rival Apprentice to win in Buena Vista.
Tevin Andrews led the Builders (13-7) with 21 points and eight rebounds, while Darrell Fenton had 16 points and eight rebounds. Johnnie Ferebee added 11 points and seven assists.
Jonathan Jacobson had 14 points and 10 rebounds for the Knights; he was one of three Jacobson brothers from Kitty Hawk, N.C., who scored in double figures.
Damion Lee knocked down 4-of-9 3-pointers en route to a game-high 20 points as host Drexel (8-11, 4-3 CAA) won its third game in a row, beating Georgia State 68-57 to end a four-game winning streak by the Panthers (10-12, 5-4).
Manny Atkins, a transfer from Virginia Tech, led GSU with 15 points and 10 rebounds. ...
Gardner-Webb (11-10, 3-4 Big South) won 63-49 at VMI (9-10, 4-3) despite 11 points and 10 rebounds from the Keydets’ D.J. Covington, a Norfolk Academy graduate. Gardner-Webb broke a 34-34 tie with a 15-2 burst. ...
Khalid Mutakabbir scored a career-high 29 as Presbyterian (5-16, 2-5 Big South) won 82-71 at Longwood (3-18, 0-7). The Blue Hose hit all 16 of their free throws. ...
Will Weeks scored 21 and Williamsburg’s Keith Hornsby 12 to help UNC Asheville beat visiting High Point 69-58. Hornsby, one of the nation’s best free-throw shooters, was just 2-of-4 at the line. ...
R.J. Price made a layup with 52 seconds left to lift Radford to a 58-57 home win over Winthrop.
More Division III
Washington and Lee shot 52 percent from the field and held on to edge Virginia Wesleyan 69-68 in Lexington, knocking the Marlins (13-5, 9-1) out of sole possession of first place in the Old Dominion Athletic Conference.
J.D. Ey scored 20 and Andrew Franz 18 for the Generals (10-9, 5-5), who led 67-59 with 2:18 left.
Menchville High graduate Chris Teasley, who had 16 points, sank a 3-pointer, then a layup with 25 seconds left to trim the margin to one. But he missed a jumper with 13 seconds left and Tre Ford missed a 3-point try at the buzzer. ...
Leon Hargrove had 15 points and six assists as Hampden-Sydney (17-2, 9-1 ODAC), ranked 23rd in Division III, won 76-52 over Guilford (14-5, 6-4).