Zeke Upshaw led the Pride (10-22) with 23 points. Four more Hofstra players — Dion Nesmith, Moussa Kone, Stephen Nwaukoni and Jamall Robinson — also scored in double figures.
The Pride shot 27-for-53 (50.9 percent) in the game compared with the Seahawks' 25-for-66 (37.9 percent).
Hofstra will face first-seeded Delaware at noon today.
Craig Ponder paced UNCW (9-23) with 24 points, and Freddie Jackson added 16 points and four rebounds.