When asked if he'll start, Osemele replied: "I think so, it looks like it."
Osemele has split time between right tackle and left guard, indicating Saturday that he'll play tackle in his NFL regular-season debut.
The development triggers a ripple effect along the line with Osemele slated to start at right tackle.
Michael Oher will shift from right tackle to left tackle, according to two league sources with knowledge of the situation.
Veteran Bobbie Williams will start at left guard against his old team.
Ravens coach John Harbaugh has always said he would start the best five linemen, and Osemele has evidently proven that he's one of the best five.
"It's not a game-time decision," Harbaugh said earlier this week in regards to Osemele's status.
When asked if Osemele will have a substantial role, Harbaugh replied: "Yes, I will confirm that. K.O. has done a good job."